Neuroprotective effects of Buchang Naoxintong Capsule on focal cerebral ischemia/reperfusion in rats
- VernacularTitle:步长脑心通胶囊对大鼠脑缺血再灌注损伤的神经保护作用
- Author:
Weiwei ZHANG
;
Yuanzheng LI
;
Linqiu QIU
- Publication Type:Journal Article
- Keywords:
Buchang Naoxintong Capsule;
neuroprotective;
cerebral ischemia/reperfusion;
vessel endothelium growth factor
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the neuroprotective effects of Buchang Naoxintong Capsule on focal cerebral ischemia/reperfusion in rats.Methods Rat model of ischemic reperfusion of cerebral middle artery was established according to Zea Longa's pattern. Rats were randomly divided into pseudo-operation group, ischemia/reperfusion group and Buchang Naoxintong Capsule treated group. The ischemia/reperfusion group and Buchang Naoxintong Capsule treated group were both divided into five subgroups according to reperfusion time or administration time such as 1 d, 3 d, 7 d, 10 d and 15 d. Using immunohistochemical staining method and color image analysis, we measured the expression of vessel endothelium growth factor (VEGF) and Laminin in the region of ischemia. Pathological changes were observed with HE staining and transmission electron microscope. Besides that, the content of brain water was assayed.Results Compared with ischemia/reperfusion group, less numbers of shrinkage or swelling neurons were found in Buchang Naoxintong Capsule treated group.The content of brain water, the expression of VEGF were obviously different between Buchang Naoxintong Capsule treated group and the other two groups (all P
