Neuroprotective effect of Gangliosides on cerebral ischemia reperfusion injury in rats
- VernacularTitle:神经节苷脂对大鼠脑缺血再灌注损伤的脑保护作用
- Author:
Jianjun LI
;
Qi SUN
;
Hui CAO
- Publication Type:Journal Article
- Keywords:
Gangliosides;
cerebral ischemia reperfusion;
apoptosis
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Gangliosides on brain protection after cerebral ischemia reperfusion injury in rats. Methods The middle cerebral artery (MCA) focal cerebral ischemia /reperfusion rat models were used by thread occlusion method. The cerebral infarct volume, neurologic function deficits and neurons apoptosis in cerebral ischemic region were observed following focal cerebral ischemia 90 min (IR 0 h) and ischemia 90 min / reperfusion 24 h (IR 24 h) by injecting Gangliosides and normal saline intraperitoneally, respectively. Results A significant reduction of infarct volume was found in the Gangliosides-treated group compared with the control group. Furthermore, Gangliosides induced significant amelioration of the number of neuron apoptosis and neurologic dysfunction following focal cerebral ischemia and reperfusion in rats (all P
