Expression of hemeoxygenase-1 and change of superoxide dismutase activity in perihematoma after intracerebral hemorrhage in rats
- VernacularTitle:大鼠脑出血后血肿周围脑组织血红素氧合酶-1表达与超氧化物歧化酶活力的变化
- Author:
Jiami WU
;
Qingwei MENG
- Publication Type:Journal Article
- Keywords:
intracerebral hemorrhage;
hemeoxygenase-1;
superoxide dismutase
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of hemeoxygenase-1 (HO-1) and change of superoxide dismutase (SOD) activity in perihematoma after intracerebral hemorrhage (ICH). Methods The rats were randomly divided into sham operating group and intracerebral hemorrhage group.Rat ICH models were induced using stereotactic infusion autologous blood 50 ?l into the caudate nucleus. At the due time, the rats were killed and brain tissues were removed for detection of HO-1 and measurement of SOD by immunohistochemical and xanthine hydrocarbonylation methods. Results Following ICH, few HO-1 positive cells were observed in brain tissue perihemota at 6 h, peaked at 48 h ( P0.05), then decreased gradually and reached the minimum at 72 h ( P0.05). The change of SOD in brain tissue perihematoma was negatively correlated with the expression of HO-1 (r=-0.878, P
