Study on plasma concentration of rifampicin in smear-positive re-treatment pulmonary tuberculosis patients after administration
- Author:
Tran Van Sang
- Publication Type:Journal Article
- Keywords:
Pulmonary tuberculosis
- MeSH:
Rifampin;
Tuberculosis;
Pulmonary
- From:Journal of Practical Medicine
2005;0(6):49-51
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
In this prospective study, 56 re-treatment pulmonary tuberculosis patients with smear-positive were examined to investigate possible variations in plasma rifampicin concentration using fixed dose combination drugs. 2-hour and 3-hour plasma rifampicin concentration were measured by HPLC method among 56 smear-positive re-treatment pulmonary tuberculosis patients. Results: Plasma rifampicin concentrations were generally low: 2-hour and 3-hour plasma rifampicin concentration below 8mg/ml (93% and 86% of patients, respectively), 55% and 46% of patients had plasma concentration below 4mg/ml (at 2-hour and 3-hour time point, respectively). Although treatment at the same dose levels, there is high variable between individual patients in plasma rifampicin concentration. Plasma rifampicin concentrations at 3 hours after dosed were higher than at 2 hours in most of patients.
