Clinical Significance of Serum Lactate Dehydrogenase and Its Isoenzymes in the Retreated Patients with Multiple Myeloma
- VernacularTitle:血清乳酸脱氢酶及其同工酶在复治多发性骨髓瘤中的临床意义
- Author:
Na LIN
;
Jinxiang YU
;
Yan LI
;
Feng GAO
;
Baixun WANG
- Publication Type:Journal Article
- Keywords:
lactate dehydrogenase;
isoenzymes;
multiple myeloma
- From:
Journal of China Medical University
2010;(1):31-33,36
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of serum lactate dehydrogenase (LDH) and its isoenzymes,M or H subunits in the retreated patients with multiple myeloma(MM).Methods 141 medical records of retreated patients with multiple myeloma were collected,and the relationship of LDH and its isoenzymes,subunits with DS staging system,ISS staging system,creatinine,bone marrow plasma cell percentage,immunoglobulin and microglobin was analyzed.Results Serum total LDH activity was not significantly related to DS staging system and ISS staging system.LDH1 percentages was negatively correlated with ISS staging system (P＜0.01),and LDH4 percentages positively associated with ISS staging system (P＜0.05).LDH activity,absolute value of LDH1 ,LDH2,LDH3,LDH4,and H subunits were positively linked to serum creatinine in myeloma kidney disease patients with renal inadequacy (P＜0.05).Both percentage and absolute value of LDH5 were negatively correlated with bone marrow plasma cell percentage (P＜0.01 and P＜0.05 respectively).Conclusion The detection of serum LDH isoenzyme is more valuable than total LDH activity in retreated patients with multiple myeloma.
