Effects of propofol on cerebrospinal fluid pressure in patients underwent intracranial operation
- VernacularTitle:异泊酚对颅脑手术中脑脊液压力的影响
- Author:
Lidong ZHANG
;
Sue FU
;
Qing JI
;
Jianguo XU
- Publication Type:Journal Article
- Keywords:
Propofol;
Cerebrospinal fluid pressure;
Intracranial operation
- From:
Journal of Medical Postgraduates
2003;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of propofol on cerebrospinal fluid pressure(CSFP),mean arterial pressure(MAP),cerebral perfusion pressure(CPP) and heart rate(HR)during induction of anesthesia in patients underwent intracranial operation. Methods: In 20 patients scheduled for elective craniotomy, an epidural catheter was placed into subarachanoid. Fentanyl(2 ?g/kg), intravenousl Midazolam (0.04~0.05mg/kg) and propofol (2mg/kg) were administered respectively prior to induction of anesthesia. CSFP,MAP,CPP and HR were monitored at 2min,5min after propofol administration and 2,5,10min after another supplementary dose of propofol 1mg/kg addendum during endotracheal intubation. Results: Compared with the preanesthetic baseline values, CSFP, CPP, and MAP all decreased significantly during induction(P
