The endothelin system and pulmonary arterial hypertension
- VernacularTitle:内皮素系统与肺动脉高压关系的研究进展
- Author:
Hao LIU
;
Zhiyong LIU
- Publication Type:Journal Article
- Keywords:
Endothelin;
Endothelial function;
Endothelial receptors;
Vasoconstriction/dilation;
Pulmonary arterial hypertension
- From:
Journal of Medical Postgraduates
2003;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Endothelin-1 (ET-1) was characterized as a powerful vasoconstrictor and mitogen for smooth muscle. ET-1 binds to two types of receptors: ET_ A-R and ET_ B-R. Pulmonary arterial hypertension (PH) is a severe condition characterized by a progressive increase in pulmonary vascular resistance. The Endothelial dysfunction plays an important role in the development of pulmonary arterial hypertension. PH can be treated by antagonism of ET-1.
