A Case of Posttransplant Lymphoproliferative Disease (PTLD) Following Renal Transplantation in a Child.
- Author:
Byung Wook EUN
1
;
Eun Sil PARK
;
Seong Yong LEE
;
Hye Won HAHN
;
Ju Young JANG
;
Kyung Mi PARK
;
Chul Woo KIM
;
Gin Han KANG
;
Jae Seong KO
;
Il Soo HA
;
Hoan Jong LEE
;
Hae Il CHEONG
;
Jeong Kee SEO
;
Yong CHOI
Author Information
1. Department of Pediatrics, Seoul National University, College of Medicine, Korea.
- Publication Type:Case Report
- Keywords:
Posttransplant lymphoproliferative disorder;
Renal transplantation;
Child
- MeSH:
Adult;
B-Lymphocytes;
Child*;
Colon;
Fever;
Ganciclovir;
Herpesvirus 4, Human;
Humans;
Hyperplasia;
Immunosuppression;
Kidney Transplantation*;
Korea;
Liver Transplantation;
Lymph Nodes;
Lymphoma, Large-Cell, Immunoblastic;
Lymphoproliferative Disorders;
Male
- From:Journal of the Korean Society of Pediatric Nephrology
2002;6(1):123-130
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Posttransplant lymphoproliferative disease (PTLD) represents a diverse lymphoproliferative disorder ranging from nonspecific reactive hyperplasia to malignant immunoblastic sarcoma developed in a setting of immunosuppression following organ or cellular transplantation. It is often associated with Epstein-Barr virus (EBV) infection and high dose immunosuppression. PTLD after renal transplantation was reported at first in adult in Korea in 1997. In children there have been several cases of PTLD after liver transplantation but PTLD after renal transplantation has not been reported. This is a case report of PTLD developed 4 months after renal transplantation in a 9-year-old boy. The major clinical manifestations were fever, multiple lymph nodes enlargement and blood-tinged stool. EBV was detected by in-situ hybridization in the enlarged cervical lymph node and the colonic tissue. Histological examination revealed B-cell lineage. Use of ganciclovir and reduction of the immunosuppression level resulted in complete remission of PTLD. This is the first pediatric case report of PTLD following renal transplantation in Korea.
