Steroid 5?-reductase and 5?-reductase type 2 deficiency
- VernacularTitle:类固醇5?-还原酶及5?-还原酶2型缺陷症研究进展
- Author:
Xueyan WU
;
Jiangfeng MAO
;
Yifan SHI
;
Jieying DENG
- Publication Type:Journal Article
- Keywords:
5?-reductase;
5?-reductase type 2 deficiency;
male pseudohermaphroditism;
inhibitory agents for 5?-reductase
- From:
Basic & Clinical Medicine
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Two types of steroid 5?-reductase isozymes were found in human and rats.5?-reductase type 2 deficiency in male lead to male pseudohermaphroditism and other related phenotypes.The content of this review includes:① The progress in the fields of 5?-reductase research;②Biochemical characteristics and physiological effects of 5?-reductase.③ Gene structure and mutation in 5?-reductase genes,clinical and chemical features of 5?-reductase type 2 deficiency syndrome.④Inhibitory agents of 5?-reductase and their mechanism and clinical use.The investigation in 5?-reductase help to illuminate physiological effect and sexual differentiation of androgen.The development of new inhibitory agents for 5?-reductase creats new strategy for diseases caused by imbalance of androgen action.Their mechanism and long effects of clinical use need further investigation and observation.
