Over expression of VMAT_(2) in CHO cells resisted toxicity of MPP~(+) and rotenone
- VernacularTitle:过表达VMAT_2的CHO细胞可抵抗rotenone和MPP~+的毒性作用
- Author:
Mingwei WANG
- Publication Type:Journal Article
- Keywords:
VMAT_(2);
MPP~(+);
rotenone;
CHO
- From:
Basic & Clinical Medicine
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study over expression of VMAT_(2) in CHO cells resisted toxicity of MPP~(+) and rotenone.Methods MTT assay was used to detect the viability of wild type china hamster ovary(WT-CHO) and over expression of VMAT_(2) cells(VMAT_(2)-CHO) with different concentrations of MPP~(+)and Rotenone,meanwhile the change of morphology was observed.Results Indicated that acted by MPP~(+) with the scope of 0.2～(2.0 mmol/L)(P
