Dihydroergocriptine increase levels of cAMP and adenylyl cyclase in hippocampus of mice with vascular dementia
- VernacularTitle:二氢麦角碱升高血管性痴呆小鼠海马cAMP和腺苷环化酶
- Author:
Peiyuan LU
;
Weibin WANG
;
Cuiping LIANG
;
Yu YIN
;
Jingfeng FAN
- Publication Type:Journal Article
- Keywords:
vascular dementia;
cAMP;
adenylyl cyclase;
dihydroergocriptine
- From:
Basic & Clinical Medicine
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the levels of cAMP and adenylyl cyclase(AC) in hippocampus of mice with vascular dementia(VD) and the effect of Dihydroergocriptine(DHE),and to explore the molecular pathogenesis of VD.Methods The mice were subjected for ischemia-reperfusion three times on bilateral common carotid arteries by knots to establish models of VD and the changes of learning and memory were tested on d29/d30 after operation.DHE was administrated to another group of mice,which was taken as treatment group.The cAMP level was evaluated by the radioimmunoassay;AC mRNA positive neurons of hippocampus CA1 area were examined through in-situ hybridization.Results Compared with shamed-operation group,the learning and memory of model group was worse(P
