Distribution and expression of peroxisome proliferator activated receptor ? in pituitary ACTH-secreting adenomas
- VernacularTitle:过氧化物酶增殖物激活受体?在人垂体ACTH腺瘤中的分布和表达
- Author:
Xuewei XIA
- Publication Type:Journal Article
- Keywords:
PPAR?;
ACTH;
adenoma;
pituitary
- From:
Basic & Clinical Medicine
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the distribution and expression of peroxisome proliferator activated receptor ?(PPAR?) in pituitary ACTH-secreting adenomas of human.Methods Immunohistochemistry and Western blot were used to identify the distribution and expression of PPAR?.Results PPAR? expressed in pituitary ACTH-secreting adenomas and normal pituitary tissues.PPAR? immunoreactivity was found in nucleoli of pituitary ACTH-secreting adenoma and normal pituitary cells.The expression in pituitary ACTH-secreting adenomas was significantly higher than that in normal pituitary tissues.Conclusion The expression of PPAR? in pituitary ACTH-secreting adenomas significantly increased,so it maybe a potential therapeutic target of pituitary ACTH-secreting adenoma.
