Protective effects of Diemailing Injection on experimental myocardial infarction in rats and its mechanism
- VernacularTitle:碟脉灵注射液对大鼠实验性心肌梗塞的保护作用及其机制
- Author:
Hongkun LI
;
Xiaofeng YU
;
Shaochun QU
;
Huali XU
;
Dayuan SUI
- Publication Type:Journal Article
- Keywords:
Diemailing Injection;
myocardial infarction;
myocardial enzyme;
free radicals;
myocardial metabolism;
blood viscosity;
vasoactive factors
- From:
Journal of Jilin University(Medicine Edition)
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the protective effects of Diemailing Injection(DMLI) on experimental myocardial infarction in rats and its mechanism.Methods The experimental myocardial infarction model was induced by left anterior descending coronary occulusion for 24 h in rats.The rats were randomly divided into sham group,myyocardial infaction model group,DMLI groups with different doses(2.5,5.0,10.0 mL?kg~(-1))(n=20).The changes of myocardial infarction size(MIS),aspartate aminotransferase(AST),actate dehydrogenase(LDH),creatine phosphokinase(CK),superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px) activities and malondialdehyde(MDA) content in serum,endothelin(ET) and angiotensinⅡ(AngⅡ) levels in plasma,and low shearing specific viscosity,middle shearing specific viscosity and high shearing specific viscosity of blood and specific viscosity of plasma were determined.At the same time,myocardial free fatty acid(FFA) contents of infarction and noninfarction area were determined.Results In rats treated by DMLI(in doses of 2.5,5.0 and 10.0 mL?kg~(-1) i.v after coronary occulusion),the MIS was significantly reduced(P
