The cellular basis of contraction in human detrusor smooth muscle from patients with stable and unstable bladders
- VernacularTitle:稳定和不稳定膀胱逼尿肌细胞收缩机制
- Author:
Wen CHENG
;
Jianping GAO
;
Zhengyu ZHANG
- Publication Type:Journal Article
- Keywords:
Unstable bladder;
Bladder detrusor smooth muscle cell;
Contraction
- From:
Journal of Medical Postgraduates
2003;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Considerable advances have been made in the understanding of the cellular processes that result in contraction and relaxation of detrusor smooth muscle recently,particularly in the role and modulation of calcium.Several changes in these cellular mechanisms that impair normal function have been observed in detrusor muscle from patients with unstable bladders.Whether these changes represent primary causes of bladder dysfunction or whether they are secondary to bladder dysfunction remains to be determined.Nevertheless,the identification of specific cellular lesions in bladder dysfunction presents a novel approach to identification of drug targets and potential treatment modalities.
