A plastic anti-infective nano-HA drug delivery implant
- VernacularTitle:可塑形抗感染纳米羟基磷灰石药粒的研制及体外释放的实验研究
- Author:
Yongfeng WANG
;
Anmin JIN
;
Shanhua TANG
- Publication Type:Journal Article
- Keywords:
Nano-hydroxyapatite(nano-HA);
Fibrin sealant;
Plastic implant;
Local drug delivery system(LDDS)
- From:
Chinese Journal of Orthopaedic Trauma
2002;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To test the releasing property of a self-developed plastic drug delivery implant of anti-infective nano-hydroxyapatite(nano-HA)so as to provide a new local drug delivery system(LDDS)for treatment of osteomyelitis.Methods The nano-HA was used as the core carrier to load gentamicin(GM).It was coated with poly hydroxybutyrate-co-hydroxyvalerate /polyethylene glycol(PHBV/PEG)to prepare the nano-HA-PHBV/PEG-GM microspheres which were mixed with the fibrin sealant(FS)to develop a plastic implant.Then its antibacte rial and in vitro releasing properties were investigated.Results The plastic LDDS implant was found to have a fine drug delivery capability.The bacterial growth inhibition zone was found around the LDDS for 56 days in the antibacterial test.Three samples were soaked with liquid of PBS(phosphate buffered saline).The titer of GM released within the first day was 154.3 ?g/mL,and then the releasing maintained a slow level in the following days.After 49 days'releasing,the titer was 6.9 ?g/mL which was still higher than the MIC(2 ?g/mL)(minima l inhibitory concentration)of GM.Conclusion The plastic LDDS has a fine in vitro releasing property and may have a widespread application in treatment of osteomyelitis.
