Development in research on relationship between statins and bone formation
- VernacularTitle:他汀类药物促进骨生成作用的基础及临床研究
- Author:
Zhusu CHEN
;
Lei ZHOU
- Publication Type:Journal Article
- Keywords:
Statins;
Osteoblast;
Bone formation;
Mechanism
- From:
Chinese Journal of Orthopaedic Trauma
2002;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Statins may not only lower cholesterol concentration,reduce the incidence of heart diseases and relieve kidney damage,but also stimulate bone formation obviously,as suggested by a number of observation studies and animal researches.However,the exact mechanism of promoting bone formation has not been very clearly yet.Moreover,their adverse effects and their interaction with other drugs still need further clinical trials.In this review,on the basis of clinical data about the effects of hydroxymethylglutaryl-CoA(HMG-CoA)reductase inhibitors,we summarize current hypotheses on their mechanism and safety,in order to provide reference for the domestic bone reconstruction research.
