Research on clinical application of BMP
- VernacularTitle:骨形态发生蛋白的临床应用方法研究进展
- Author:
Benxiang YUAN
;
Yinghai DONG
- Publication Type:Journal Article
- Keywords:
Bone morphogenetic protein;
Bone;
Growth factors;
Carrier;
Gene therapy
- From:
Chinese Journal of Orthopaedic Trauma
2002;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Bone Morphogenetic Proteins(BMPs)belong to the Transforming Growth Factor beta(TGF-?)family and play pivotal roles in osteogenesis,induction,maintenance and repair of bone.Differentiation of osteoprogenitor mesenchymal cells and up-regulation of osteoblastic features depend on the expressing level of BMPs.Because of their osteogenic potential,BMPs have tremendous potentia l as therapeutic agents in healing fractures of bone,preventing osteoporosis,healing of spinal fusion,treating periodontal defects and enhancing bone formation around alloplastic materials implanted in bone.Some mature products have been invented and available in market.This article reviews available therapeutic preparations of BMPs,involving carriers implanted for slow release,closed local injection and gene therapy,and suggests future applications likely to develop from current investigations.
