Studies on relationship between resistance to vancomycin and changes of coagulase gene sequences of S.aureus
- VernacularTitle:金黄色葡萄球菌万古霉素体外诱导中介株凝固酶基因序列改变
- Author:
Hong DAI
;
Xuegong FAN
- Publication Type:Journal Article
- Keywords:
vancomycin;
drug resistibility;
coagulase;
gene sequences
- From:
Chinese Journal of Clinical Laboratory Science
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To induce vancomycin-resistantant S.aureus in vitro and to observe the changes of coagulase gene sequences of S.aureus and its relationship with vancomycin resistance.Methods DNA sequences of the coagulase were examined by polymerase chain reaction-sigle strand conformation polymorphism(PCR-SSCP) method and were identified by sequencing.Results The altered DNA sequence of coagulase in 1 strain of S.aureus was found.Conclusion The variation of DNA sequences of coagulase gene is probably linked to vancomycin-resistance in S.aureus.
