Effect of Topiramate on Spatial Learning and Memory of KA-induced Rats
- VernacularTitle:托吡酯对海藻酸致痫大鼠空间学习记忆能力的影响
- Author:
Xiangping XU
;
Ruopeng SUN
;
Ruifeng JIN
- Publication Type:Journal Article
- Keywords:
topiramate;
epilepsy;
animal study;
kainate acid;
learning;
memory
- From:
Chinese Mental Health Journal
1989;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the chronic effect of topiramate on spatial learning and memory to young rats. Methods:P28 KA-induced rats were used. After 8-week treatment of topiramate, spontaneous recurrent seizures were recorded; Spatial learning and memory ability was evaluated by Morris water maze. Results: TPM-treated rats had significantly fewer(3.50?3.84) spontaneous recurrent seizures than rats without TPM treatment(7.36?3.75). On the first day of Morris water maze, they also had statistically longer latency to the platform(590.6?230.9 s) than those from the group without TPM treatment (422.6?122.3 s), but no latency differences were found in the following three days. TPM had no effect on water maze performance to rats without KA induction. After three days of interval, no differences were found in all groups under the same experimental situation.Conclusion:For developing rat brain, TPM has no impairment on the ability of long-term memory and information retrieval meanwhile its negative effect on spatial learning is temporary.
