Relationship between invasiveness and expression of ER、PGTT、bFGF in human prolactinomas
- VernacularTitle:人泌乳素腺瘤中ER、PTTG、bFGF的表达与肿瘤侵袭性的关系
- Author:
Youqiang CUI
;
Liangzhu TENG
;
Guoxin LI
;
Qi PANG
- Publication Type:Journal Article
- Keywords:
prolactinomas;
estrogen receptor;
pituitary tumor transforming gene;
basic fibroblast growth factor
- From:
Basic & Clinical Medicine
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between invasive growth and expression of ER、PTTG、bFGF in human prolactinomas.Methods Fourty-six prolactinomas specimens were collected and divided into invasive group and non-invasive group.Expressions of ER、PTTG、bFGF were examined by immunocytochemical method.Total RNA was extracted from specimens and ER-mRNA and PTTG-mRNA were detected by RT-PCR.Results IA of protein expression of ER、bFGF、PTTG in invasive prolactinomas was seperately 5385.1?1348.6、9874.2?2143.7、7938.5?1436.5;The optical density ratio of ER-mRNA and PTTG-mRNA was 0.71 and 0.83,difference between invasive group and non-vasive group was significant.Conclusions ER、PTTG、bFGF in human prolactinomas closely correlated with invasiveness of prolactinomas,and may play important function in prolactinomas.
