The effects of rosiglitazone on the endothelial regeneration and neointimal formation of balloon injured rat aortic
- VernacularTitle:罗格列酮对大鼠胸主动脉球囊损伤后内皮再生和内膜增生的影响
- Author:
Yuan YAO
;
Hong JIANG
;
Chao XU
- Publication Type:Journal Article
- Keywords:
Rosiglitazone;
Tunica intima;
Endothelium
- From:
Chinese Journal of Interventional Cardiology
1996;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of rosiglitazone on the endothelial regeneration and neointimal formation after balloon injury in rat aortic.Methods Endothelial denudation of aorta in SD rats were performed with 2 F Fogarty balloon catheter.Male Rats were randomly divided into the sham-operated group,the control group,and the RSG group.Aortic tissues were harvested 7 days and 14 days after the injury.The endothelial regeneration rate,serum NO level,IA/MA ratio and PCNA expression index were detected.Results RSG enhanced the reendothelialization of the injured aorta determined by Evans blue staining.The RA/TA ratio on the 7~(th) day and the 14~(th) day were 38.20% and 75.20%(P
