Study of protective effect of Ginkgo Biloba extract on rat brain with cerebral ischemia/reperfusion
- VernacularTitle:银杏叶提取物对缺血再灌注鼠脑保护作用的研究
- Author:
Xiaoshan WANG
;
Qing DI
;
Hui CAO
- Publication Type:Journal Article
- Keywords:
MRI;
~1H-MRS;
cerebral ischemia;
Ginkgo Biloba extract
- From:
Journal of Clinical Neurology
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the protective effect of Chinese traditional medicine Ginkgo Biloba extract on rat brain with cerebral ischemia/reperfusion.Methods Compared with ischemia/reperfusion group, Ginkgo Biloba extract-treated group was observed the change of ischemia and edema volume and NAA and lactate in by DWI and ~1H-MRS examination after cerebral ischemia /reperfusion 1 h,3 h,6 h. Results A significant reductions in infarct volume were found in the Ginkgo Biloba extract-treated group compared with the control group after cerebral ischemia 60 min/reperfusion 1 h,3 h,6 h. Ginkgo Biloba extract could decrease the concentration of Lac/(PCr+Cr) and prevent the decline of the concentration of NAA /(PCr+Cr) after cerebral ischemia/reperfusion, it had significantly difference compared with the control group(all P
