The regulatory effect of tissue plasminogen activator involved in central nervous insult
- VernacularTitle:组织型纤溶酶原激活物在中枢神经损伤中的调节作用
- Author:
Lin PENG
;
Xia HUO
;
Xijin XU
- Publication Type:Journal Article
- Keywords:
Tissue plasminogen activator;
Excitotoxity;
Neurodegeneration
- From:
Journal of Medical Postgraduates
2004;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Tissue plasminogen activator(tPA) had been used clinically as a choice drug for the therapy of ischemic shock.Evidence in animal experiments suggests that tPA may play a neurotoxic role in central nervous system(CNS) via the induction of microglial activation,degradation of laminin matrix and enhancement of the N-methyl-D-aspartate(NMDA) receptor-mediated signaling in neurons,other reports imply tPA could protect rat neuronal cells from zinc-induced toxicity.
