The relationship between T~(-786)→C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene and type 2 diabetes with coronary heart disease
- VernacularTitle:内皮一氧化氮合酶基因5′-侧翼区T~(-786)→C突变与2型糖尿病并发冠心病的关系
- Author:
Guangda XIANG
;
Hong LIU
;
Jie HOU
- Publication Type:Journal Article
- Keywords:
Endothelial nitric oxide synthase;
T~(-786)→C mutation;
Diabetes mellitus,type 2;
Coronary heart disease.
- From:
Chinese Journal of Diabetes
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between T~(-786)→C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene and type 2 diabetes(T2DM) with coronary heart disease(CHD). Methods One hundred and eighty-six T2DM were selected,and of them,65 had CHD.Meanwhile,63 healthy individuals were selected as control.PCR/ASO(allele-specific oligonucleotide probe) technique was used to determine the T~(-786)→C mutation.Results Compared with control,the T/C genotype and C allele prevalences were significantly higher in T2DM with CHD(P
