Expression of connective tissue growth factor(CTGF) in kidney of type 2 diabetes mellitus and its clinical significance
- VernacularTitle:肾脏结缔组织生长因子的检测及其对糖尿病肾病早期诊断的价值
- Author:
Houqin XIAO
;
Jiane ZHANG
;
Guohua DING
- Publication Type:Journal Article
- Keywords:
Connective tissue growth factor;
Diabetic nephropathy;
Albuminuria
- From:
Chinese Journal of Diabetes
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate expression of connective tissue growth factor(CTGF) in the kidney of patients with type 2 diabetic mellitus(DM) as well as its clinical significance.Methods Fourty cases with DM were divided into three groups: normal albuminuric group(200 ?g/min,n=12).The urinary excretion rates of CTGF were determined by ELISA in all the cases and 30 subjects of control.Twenty cases of them received renal biopsy.Expression of CTGF in kidney among different groups were detected by immunohistochemical stainning.Results Expression of CTGF in kidney elevated significantly in DM as compared with group of normal control.At the same time the excretion rates of CTGF in DM groups were markedly higher than that in control(P
