The high fat-feeding induces macrovascular disease through activation of NF-?B in rat
- VernacularTitle:NF-?B导致高脂饲养大鼠大血管病变
- Author:
Yujun XIAO
;
Yiming MU
;
Changyu PAN
- Publication Type:Journal Article
- Keywords:
Fatty acid;
Insulin resistance;
Vasculr diseases;
Nuclear factor-?appa B
- From:
Chinese Journal of Diabetes
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mechanism of endothelial cell damage under insulin resistance state induced by high fat-feeding by observations of the effects of antioxidant N-acetylcysteine(NAC) on the blood glucose,lipids,the histological parameters of aorta,and the expression of intercellular adhesion molecules-1(ICAM-1),monocyte chemoattractant protein-1(MCP-1) and NF-?B/I?B? in aortic intima.Methods Forty-five Wistar male rats aged 5 to 6 weeks were randomly divided into 3 groups:control,high fat-feeding(HF) and HF plus NAC treatment(HF+NAC).Blood glucose,insulin,lipids,body weight,visceral fat content,histological change of aorta and the expression levels of ICAM-1,MCP-1 and NF-?B/I?B? were determined after the rats were fed for 11 weeks. Results(1)The body weight,ratio of visceral fat content over body weight,blood glucose,insulin,triglyceride,total cholesterol,LDL-C,and total FFA were significantly increased in HF group after 11 weeks feeding compared with control or HF+NAC(all P
