Effects of hepatitis C virus persistent infection on biological behavior of human placental syncytiotrophoblast in vitro
- VernacularTitle:丙型肝炎病毒持续感染对体外培养人胎盘合体滋养层细胞生物学性状的影响
- Author:
Yafei ZHANG
- Publication Type:Journal Article
- Keywords:
Hepatitis C virus;
Syncytiotrophoblast;
Biological behavior;
In vitro
- From:
Journal of Medical Postgraduates
2004;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effect of HCV persistent infection on biological behavior of human placental syncytiotrophoblast in vitro. Methods: Using Matrigel invasion assay,cell adhesive assay and migration assay to measure the effect of HCV persistent infection on invasive and relative adhesive and migration ability of human placental syncytiotrophoblast in vitro.Content of HCG in supernatant of the cultured medium was detected to evaluate the change of hormone synthesis and secretion of the infected syncytiotrophoblast.Results: Ability of invasion,adhesion,migration and function of hormone synthesis and secretion of infected syncytiotrophoblast decreased significantly in comparison with cells of control group(P
