Association between glucocorticoid receptor gene G1666T polymorphism and essential hypertension
- VernacularTitle:糖皮质激素受体基因G1666T多态性与原发性高血压的相关性
- Author:
Lanqin CHI
;
Chen ZHANG
;
Mingjun SONG
;
Fengcui SUN
- Publication Type:Journal Article
- Keywords:
hypertension;
glucocorticoid receptor;
gene polymorphism;
PCR-RFLP
- From:
Basic & Clinical Medicine
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the association between human glucocorticoid receptor gene G166T polymorphism and essential hypertension(EH).Methods DNA samples from 71 normotensive cases and 48 EH cases were analyzed by a polymerase chain reaction(PCR) for restriction fragment length polymorphism(RFLP) to determine the intron 4 variant of human glucocorticoid receptor gene.Results No association was observed between EH group and control group.However,in females,a little association was observed between the EH group and control group.Frequencies of allele G were 0.64 in EH group and 0.46 in control group.Conclusion The G allele may be a predisposing gene marker,HGR gene intron 4 polymorphism contributes to the development of EH in females.
