Inhibitory effect of Mycobacterium tuberculosis induced condition medium on macrophage response to IFN-?
- VernacularTitle:结核分枝杆菌诱导巨噬细胞产生的条件培养基对?-干扰素信号转导系统的抑制作用
- Author:
Ke WANG
;
Ranwei LI
;
Lianzhi GU
;
Zhongsen MA
- Publication Type:Journal Article
- Keywords:
Mycobacterium tuberculosis;
macrophages;
IFN type II;
interleukin-6
- From:
Journal of Jilin University(Medicine Edition)
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Objective To study the effect of Mycobacterium tuberculosis (Mtb) on IFN-? signaling pathway in macrophages. Methods Humans and mice macrophages were isolated and infected by Mtb, condition medium were collected after a few days culture; Macrophage surface expression of Fc?RI (human) or MHC II (mouse) was measured by flow cytometry to explore the effect of condition medium on macrophage response to IFN-?. Results Surface expression of Fc?RI in human macrophages cultured in condition medium was significantly decreased compared to those without condition medium (p
