Ameliorative effects of pseudoginsenoside GQ on isoproterenol-induced acute myocardial ischemia in rats
- VernacularTitle:伪人参皂苷GQ对异丙肾上腺素致大鼠急性心肌缺血的改善作用
- Author:
Jinping LIU
;
Chunfang ZHAO
;
Pingya LI
;
Xian LI
- Publication Type:Journal Article
- Keywords:
pseudoginsenoside GQ;
myocardial ischemia/drug therapy;
myocardial ischemia/chemically induced;
isoproterenol/advarse effects;
electrocardiogram
- From:
Journal of Jilin University(Medicine Edition)
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the ameliorative effects of pseudoginsenoside GQ (PGQ) on electrocardiogram changes in rats with acute myocardial ischemia induced by isoproterenol (ISO). Methods 50 Wistar rats were divided into five groups (n=10) randomly. Group I : i. v. 0.9% sodium chloride water liquor; Group II : i. v. verapamil hydrochloride of 0. 2 mg ? kg-1 ; Group III : i. v. 3. 0 mg ? kg-1 of PGQ; Group IV : i. v. 6. 0 mg ? kg-1 of PGQ; Group V : i. v. 12. 0 mg ? kg-1 of PGQ. Myocardial ischemia was induced by intravenous injection of ISO (2.0 mg ? kg-1). ST-segment changes in the lead II , precordial in lead V1 and precordial in lead V2 were examined. Results In lead II , lead precordial V 1 and lead precordial V 2 , ST-segment elevation of three PGQ groups were not obvious at every time point, the extents of ST-segment elevation were lower than those in sodium chloride water liquor group (P
