Preparation of porous nano-hydroxyapatite/collagen composite and its capability
- VernacularTitle:多孔纳米羟基磷灰石／胶原复合材料的制备及性能
- Author:
Ning MA
;
Yi ZENG
;
Li ZHANG
;
Haibin YANG
;
Ming ZHANG
- Publication Type:Journal Article
- Keywords:
hydroxyapatites;
collagen;
tissue engineering;
bone substitutes
- From:
Journal of Jilin University(Medicine Edition)
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the simple preparation method and structure of nano-hydroxyapatite/collagen composite, to investigate new substitute of repairing bone for using in tissue engineering. Methods Porous nano-hydroxyapatite was made of Ca (OH)2 and H3PO4. Collagen was drawn from fresh adult bovine tendon. The two materials were prepared into biomembrane through the glutaraldehyde and freeze-drying. The crystallite phase, micro-morphology, structure, crystallite size of the composite were examined by XRD and scanning electronic microscop (SEM). Results The results showed that the composite structure was porous and consisted of nano-hydroxyapatite (10 nm ? 50 nm - 20 nm ? 80 nm) and collagen fiber. The crystallite phases and size of the composite was similar to that of natural bone. Conclusion The porous nano-hydroxyapatite /collagen composite is expected to be an ideal substitute of repairing bone.
