Expressions of matrix metalloproteinases-2 and its tissue inhibitor-2 and microvessel density in endometrial carcinoma
- VernacularTitle:基质金属蛋白酶-2及其组织抑制剂和微血管密度在子宫内膜癌中的表达
- Author:
Yujing ZHANG
;
Liping GU
;
Ying HUA
;
Shoujie ZHANG
- Publication Type:Journal Article
- Keywords:
endometrial neoplasms;
gelatinase A;
tissue inhibitor of metalloproteinases;
neovascularization, pathologic;
micro vascular density
- From:
Journal of Jilin University(Medicine Edition)
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expressions of matrix metalloproteinases-2 (MMP-2) and its tissue inhibitor-2 (TIMP-2) and microvessel density (MVD) in human endometrial carcinoma tissues and their relations with the invasion and metastasis of endometrial carcinoma. Methods Immunohistochemistry was used to measure the MMP-2, TIMP-2, and MVD protein levels in 33 patients with endometrial carcinoma and 8 normal endometrial samples. Results The MMP-2, TIMP-2 and MVD protein expressed in both normal endometrial samples and endometrial carcinoma. The positive expression proportions of MMP-2, TIMP-2, and MVD protein in endometrial carcinoma tissues were higher than those in normal endometrial samples (P
