Relationship between oncogene Stat3 and invasion and metastasis of non-small cell lung cancer
- VernacularTitle:癌基因Stat3与非小细胞肺癌侵袭和转移的关系
- Author:
Yaxin SUN
;
Zhichao ZHANG
;
Chuanjie XU
;
Chunlei YU
- Publication Type:Journal Article
- Keywords:
carcinoma, non-small cell lung;
Stat3;
CyclinD1;
proliferating cell nuclear antigen;
neoplasm invasiveness;
neoplasm metastasis;
immunohistochemistry
- From:
Journal of Jilin University(Medicine Edition)
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of Stat3, CyclinD1 and proliferating cell nuclear antigen (PCNA) in non-small cell lung cancer (NSCLC), and analyze their relationships with carcinogenesis and progression of NSCLC. Methods SP immunohistochemistry was used to detect the expressions of Stat3, CyclinD1 and PCNA in 45 cases of NSCLC. Results The positive rate of Stat3 was 71. 1 % in NSCLC. The expression intensities of Stat3 was not associated with different tumor sizes and histological type, but it was associated with the expression intensities of CyclinDi and PCNA (r= 0.531, P
