Correlations of matrix metalloproteinase content and expression with invasion and metastasis of hepatocellular carcinoma
- VernacularTitle:基质金属蛋白酶含量及表达与肝细胞癌侵袭转移的关系
- Author:
Zhichao ZHANG
;
Yaxin SUN
;
Mingku JIA
- Publication Type:Journal Article
- Keywords:
carcinoma, hepatocellular;
gelatinase A/blood;
gelatinase A/chemistry;
gelatinase B/blood;
gelatinase B/chemistry;
neoplasm invasion;
neoplasm metastasis
- From:
Journal of Jilin University(Medicine Edition)
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlations of serum matrix metalloproteinase-2, -9 (MMP-2, MMP-9) contents and tissue expressions in hepatocellular carcinoma with tumor invasion and metastasis. Methods Serum MMP-2, MMP-9 contents were detected in 40 patient with hepatocellular carcinoma and 20 healthy controls by ELISA; the expressions and distributions of MMP-2 and MMP-9 in 40 patients and 10 normal tissues were detected by immunohistochemical method. Results Serum MMP-2, MMP-9 contents were significantly elevated in cancer samples compared with normal serum (P
