Antimicrobial Activity in vitro of ?-Lactams and ?-Lactamase Inhibitors Against Bacteria of Hospital Acquired Infection
- VernacularTitle:?-内酰胺类抗菌药物及其复合制剂对医院感染菌株体外抗菌活性研究
- Author:
Peilan WANG
;
Wei SU
;
Youning LIU
;
Rui WANG
- Publication Type:Journal Article
- Keywords:
?-Lactams;
?-Lactamase inhibitors;
Antimicrobial activity
- From:
Chinese Journal of Nosocomiology
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE Tostuty the antimicrobial activity in vitro of 13 ?-lactams and the combinations of (?-lactams) and(?-lactamase) inhibitors against 84 isolates of Klebsiella pneumoniae and Escherichia coli.METHODS MICs were determined by agar dilution method.RESULTS The antimicrobial activity of combinations of ?-lactams and(?-lactamase) inhibitors was the strongest,and the activity of ?-lactams and qinolones were inferior,and ?-lactams were invalid.CONCLUSIONS In the antimicrobial spectrum and antimicrobial activity the combinations of ?-lactam and ?-lactamase inhibitors were stronger than that of ?-lactam.The use of combinations of ?-lactam and ?-lactamase(inhibitors) may increase the clinical cure rate,and delay the occurrence of resistance.
