Influence of menopause on high density lipoprotein-cholesterol and lipids.
10.3346/jkms.2000.15.4.380
- Author:
Chee Jeong KIM
1
;
Tae Ho KIM
;
Wang Seong RYU
;
Un Ho RYOO
Author Information
1. Department of Internal Medicine, Chung-Ang University Medical Center, Seoul, Korea. cjkim+AEA-cau.ac.kr
- Publication Type:Original Article ; Comparative Study ; Research Support, Non-U.S. Gov't
- Keywords:
Hormones;
Female;
Lipoproteins;
Lipids;
Menopause
- MeSH:
Apolipoproteins A/blood;
Arteriosclerosis/epidemiology;
Biological Markers;
Cholesterol/blood;
Comparative Study;
Cross-Sectional Studies;
FSH/blood;
Female;
Human;
Lipids/blood+ACo-;
Lipoprotein(a)/blood;
Lipoproteins, HDL Cholesterol/blood+ACo-;
Menopause/blood+ACo-;
Middle Age;
Postmenopause/blood;
Premenopause/blood;
Risk Factors
- From:Journal of Korean Medical Science
2000;15(4):380-386
- CountryRepublic of Korea
- Language:English
-
Abstract:
It has been generally accepted that high density lipoprotein cholesterol (HDL-C) level decreases with menopause in women. However, recent reports show different results. There is very little data concerning perimenopausal women. To verify these findings, lipids and lipoprotein(a) +AFs-Lp(a)+AF0- levels were compared among pre-, peri- and postmenopausal women of similar mean ages. Postmenopausal women had higher HDL-C levels than premenopausal women (p+ADw-0.001) and there was no difference between peri- and postmenopausal women. LDL-C level in perimenopausal women was lower than in postmenopausal women (p+ADw-0.001) and higher than in premenopausal women with borderline significance (p+AD0-.051). Total cholesterol levels showed stepwise elevation from premenopause to postmenopause. Perimenopausal women had lower Lp(a) levels than postmenopausal women (p+ADw-0.0005) and similar levels to premenopausal women. Lp(a) levels between 0.1 to 10.0 mg/dL were the most prevalent in pre- and perimenopausal women, and those between 10.1 to 20.0 mg/dL in postmenopausal women. In conclusion, menopause itself is associated with the elevation of HDL-C level, and the postmenopausal increase of coronary artery disease is not related to postmenopausal change of HDL-C level. Perimenopausal status, although transient, may favor Lp(a) and lipid profiles for delaying atherosclerosis.
