Risk Factors for Infections in Patients with Cirrhosis: A Case-control Study
- VernacularTitle:肝硬化合并感染危险因素的病例对照研究
- Author:
Hong WANG
;
Bo ZHANG
- Publication Type:Journal Article
- Keywords:
Cirrhosis;
Infection;
Risk factors
- From:
Chinese Journal of Nosocomiology
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To identify the risk factors for infections in patients with cirrhosis.METHODS A case-(control) study was employed.A total of 286 patients hospitalized between 1999 and 2003 were included in.Patients who developed infection complication were defined as case,the remains were as control.The data of possible risk factors,including serum levels of albumin(Alb),prothrombin time(PT),total bilirubin(T-Bil),Child-Pugh score,ascite,esophageal variceal bleeding,total cholesterol(T-chol),other complication,the total white blood cell(wbc),surgery,and days of hospitalization,were retrospectively collected.According to multivariate Logistic regression model,the potential risk factors were assessed.RESULTS Infections developed in 127((44.4%))(patients) and 100(78%) of those developed infection during hospitalization.The mortality rate of case was(20.5%,) which was significant higher than that of control(3.1%,P0.08).Fifty five patients(30.7%) had spontaneous bacterial peritonitis(sbp).Bacterial culture of samples were prepared from 97 of 127 patients((76.4%),) and was positive in 62(63.9%) patients.From these culture-positive samples,35(56.4%)(samples) were Gram-negative bacterial strains,8 of 15 samples from patients developed sepsis were Gram-positive bacteria.On multivariate analysis,the Alb level and days of(hospitalization) were the independent risk factors for cirrhosis patients with infection complication.The odds ratio was 0.33(95% CI(0.32)-0.55),and 0.23(95% CI(0.14)-(0.38),) respectively.CONCLUSIONS Patients with advanced cirrhosis with low Alb level and long days of(hospitalization) should be carefully treated,and administration of broad spectrum antibiotic covering Gram-positive bacteria needs to be considered in treatment of sepsis.
