Clinicopathologic study of Castleman's disease in Korea.
10.3346/jkms.2000.15.4.393
- Author:
Ji Eun KIM
1
;
Chong Jai KIM
;
In Ae PARK
;
Woo Ho KIM
;
Jeong Wook SEO
;
Ja Jun JANG
;
Chul Woo KIM
;
Seong Hoe PARK
;
Hyun Soon LEE
;
Je G CHI
;
Yong Il KIM
;
Eui Keun HAM
Author Information
1. Department of Pathology, Seoul National University College of Medicine, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't ; Review
- Keywords:
Giant Lymph Node Hyperplasia;
Herpesvirus, Kaposi Sarcoma-Associated;
Sarcoma, Kaposi;
Dendritic Cells, Follicular;
Interleukin-6;
Intercellular Adhesion Molecule-1
- MeSH:
Adolescence;
Adult;
Biological Markers;
Dendritic Cells, Follicular/pathology;
Epstein-Barr Virus Infections/virology;
Epstein-Barr Virus Infections/epidemiology;
Female;
Germinal Center/pathology;
Giant Lymph Node Hyperplasia/virology;
Giant Lymph Node Hyperplasia/pathology+ACo-;
Giant Lymph Node Hyperplasia/epidemiology;
Giant Lymph Node Hyperplasia/classification;
Herpesviridae Infections/virology;
Herpesviridae Infections/epidemiology;
Herpesvirus 4, Human/isolation +ACY- purification;
Herpesvirus, Kaposi Sarcoma-Associated/isolation +ACY- purification;
Human;
Hyperplasia;
Intercellular Adhesion Molecule-1/analysis;
Interleukin-6/analysis;
Korea/epidemiology;
Lymph Nodes/virology;
Lymph Nodes/pathology;
Lymph Nodes/chemistry;
Male;
Middle Age;
Neovascularization, Pathologic;
Receptors, Complement 3d/analysis;
Retrospective Studies;
Tumor Virus Infections/virology;
Tumor Virus Infections/epidemiology
- From:Journal of Korean Medical Science
2000;15(4):393-398
- CountryRepublic of Korea
- Language:English
-
Abstract:
Castleman's disease represents an atypical lymphoproliferative disorder, infrequently associated with various immunologic abnormalities or subsequent development of malignancy such as Kaposi sarcoma, malignant lymphoma and plasmacytoma. Its clinicopathologic features depend on various etiologic factors such as Kaposi sarcoma herpesvirus (KSHV), oversecretion of IL-6, adhesion molecule and follicular dendritic cell dysplasia, etc. To investigate the relationship of Castleman's disease (CD) and the above factors, we reviewed 22 cases of CD. Four cases of KSHV positive CD were detected, all multicentric, plasma cell type, and these cases displayed prominent vascular proliferation, characteristic 'Kaposi-like lesion'. IL-6 and CD54 positive mononuclear cells were scattered in interfollicular areas of KSHV positive cases. Follicular dendritic cell hyperplasia, vascular proliferation, expression of IL-6 and CD54 did not show any significant difference between solitary vs multicentric type, and plasma cell type vs hyaline vascular type. Our study suggests that KSHV positive CD reveals unique pathologic features, and the probable relationship of KSHV and IL-6 and CD54 is discussed.
