Future use of protein microarrays for diagnosing early injuries of articular cartilage
- VernacularTitle:应用蛋白芯片技术诊断早期关节软骨损伤的展望
- Author:
Qi CHANG
;
Changlin HUANG
- Publication Type:Journal Article
- Keywords:
Articular cartilage injury;
Protein microarrays;
Biological Marker
- From:
Chinese Journal of Orthopaedic Trauma
2002;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
As a high-throughout technique after DNA chips in biomedical research, protein arrays are developing, with high sensitivity and veracity. They have drawn increasing attention because they can provide a new technological platform for life science studies. There has been no effective diagnosis instrument for common articular cartilage injuries when they are at an initial stage, but when the disorders progress into an advanced stage, visible functional disturbances often arise. Protein arrays may offer a solution to the lasting tough problem in orthopaedic field. In this paper, we review the development and research of protein arrays, the regulation of proteins, their biochemical functions and their potential interaction partners, as well as changes of cartilage biomarkers in body fluid after injury. In addition, the feasibility and rationality of using protein microarrays for diagnosing early articular cartilage injuries are discussed.
