Effect of Corticosterone on Morphine-induced Psychomotor Effect and Its Sensitization
- VernacularTitle:皮质酮对吗啡急性精神运动兴奋性及行为敏感化的影响
- Author:
Dongmei WANG
;
Yonghui LI
;
Xigeng ZHENG
- Publication Type:Journal Article
- Keywords:
drug addiction;
animal study;
morphine;
psychomotor activity;
sensitization$$$$
- From:
Chinese Mental Health Journal
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the role of corticosterone in morphine-induced acute psychomotor activity and behavioral sensitization.Methods: 32 male SD rats were divided into four groups. Rats were intraperitoneally given saline, morphine, corticosterone and corticosterone/morphine separately. The horizontal locomotor activity was recorded for 60min by the computer trace system automatically. The locomotor activity was measured in every two days for total seven times. Results:The corticosterone/morphine group showed significant morphine-induced acute psychomotor effect comparing with the saline group(saline group 7175?676, corticosterone/morphine group 10365?503,P
