Effects of ginkgo biloba extract 761 on contraction of gastrocnemius of fixed hindlimb in rats
- VernacularTitle:银杏叶提取物EGb761对后肢固定大鼠腓肠肌收缩功能的影响
- Author:
Zhi HUANG
;
Bin YU
;
Jie ZHU
- Publication Type:Journal Article
- Keywords:
Ginkgo biloba extract;
Disused atrophy;
Skeletal muscle;
Wet weight;
Contraction
- From:
Chinese Journal of Orthopaedic Trauma
2004;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the preventive and therapeutic effects of ginkgo biloba extract 761 on disused skeletal muscle atrophy by observing its effects on the wet weight, protein content and contraction of the gastrocnemius of fixed hindlimb in rats. Methods 24 SD rats were divided into blank group, contrast group and experimental group. Their right hind limbs were fixed for 4 weeks with plastic plaster from metatarsus to 1 cm up the knee. The knee joint was fixed in 100? flexion and the ankle joint in 60? plantar flexion. Rats in the contrast group were perfused with 3mL distilled water, and rats in the experimental group were perfused with ginkgo biloba extract 761 (120 mg/kg, 14 mg/mL). The whole gastrocnemius muscle of the right hindlimb was dissected 4 weeks later to measure its contract tension, wet weight and protein content. Results Compared with the blank group, single maximal contraction, maximal tetanus, wet weight and protein content of the gastrocnemius muscle in the contrast and experimental groups decreased significantly (P
