Study of adhesion molecules ?_2 integrin CD11c and CD18 expressions of peripheral blood leukocytes in patients with acute ischemic stroke
- VernacularTitle:急性缺血性卒中患者外周血白细胞表面黏附分子?_2整合素CD11c、CD18表达的研究
- Author:
Wenwei XIA
;
Xuexu ZHAO
;
Zuohan LI
- Publication Type:Journal Article
- Keywords:
leukocyte;
adhesion molecules;
flow cytometer;
ischemic stroke
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and significance of adhesion molecules ?2 integrin CD11c, CD18 in the polymorphonuclear neutrophils (PMN) and mononuclear leukocytes (MNL) of peripheral blood in patients with acute ischemic stroke (AIS).Methods Using indirect immunofluorescence and adopting a flow cytometry, the expressions of CD11c, CD18 in PMN and MNL in peripheral blood were measured within 72 h and 7 d after onset in 28 patients and 28 healthy controls.Results In AIS group, the expressions of CD11c, CD18 in PMN and MNL within 72 h ( 20.82?5.88, 218.25?89.00, 34.78?14.56 and 286.75?95.50, respectively) and at 7 d ( 18.60?5.52, 185.52?68.44, 31.97?14.47and 247.00?88.06, respectively) were significantly higher than those of normal control group ( 15.63?3.01, 150.76?41.20, 20.20?8.50 and 186.38?52.97, respectively)(all P
