Experimental study of the relationship between the changes of GABAergic interneurons and temporal lobe epilepsy
- VernacularTitle:?-氨基丁酸能中间神经元的数量变化与颞叶癫疒间关系的实验研究
- Author:
Niangui XU
;
Bo XIAO
;
Guoshuai YANG
- Publication Type:Journal Article
- Keywords:
GABAergic interneurons;
temporal lobe epilepsy;
immunohistochemistry
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systemically discuss the role of Parvalbumin (PV), Calretinin (CR) and Calbindin-D28k (CB)-containing GABAergic interneurons in the acute onset and development of temporal lobe epilepsy.Methods Immunohistochemistry method was used to detect the changes of PV, CR and CB-containing interneuron numbers in hippocampus of temporal lobe epileptic rats induced by lithium-pilocarpine at different time points (6 h, 24 h, 7 d, 15 d, 30 d and 60 d).Results Compared with control group, no loss of PV-positive cells was observed in CA3 region at any time point in epileptic model groups, while dramatic reduction of PV-positive cells was seen in CA1 region ( P0.05). In CA1 region, the number of CB positive interneurons decreased dramatically at 6 h ( P
