Effects of estrogen on striatal neurons damage in rats induced by quinolinic acid
- VernacularTitle:雌激素对喹啉酸致大鼠纹状体神经元损害的影响
- Author:
Guoqing ZHOU
;
Jinxia LIU
;
Xinfeng LIU
- Publication Type:Journal Article
- Keywords:
estrogen;
quinolinic acid;
Huntington's disease
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of estrogen on striatal neurons damage in rats induced by quinolinic acid (QA).Methods Ovariectomized rats were divided into two groups:non-replacement treatment group (recievied intrastriatal application of QA alone) and replacement treatment group (received both QA and 17-? estradiol). Striatal neurons injury was evaluated using NADPH-diaphorase histochemistry and the rotation number of rats induced by apomorphine was recorded. Activity of SOD and contents of MDA in striatum was measured by xanthine oxidase and thio-barbital method, respectively.Results Compared with non-replacement treatment group, there was a significant increase in the number of NADPH-diaphorase positive neurons ( P
