Intervention effect of recombinant hirudin on inflammatory reaction in perihematoma of rats with intracerebral hemorrhage
- VernacularTitle:重组水蛭素对大鼠脑出血血肿周边组织炎性反应的干预作用
- Author:
Zhonghe ZHOU
;
Fang QU
;
Xiang HE
- Publication Type:Journal Article
- Keywords:
intracerebral hemorrhage;
thrombin;
hirudin
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the intervention effect of recombinant hirudin on inflammatory reaction in perihematoma of rats with intracerebral hemorrhage(ICH).Methods ICH models of rats were established by autologous blood injection. Recombinant hirudin was injected into hematoma immediately, 6 h, 12 h after operation, then the expressions of TNF-? and ICAM-1 were detected and myeloperoxidase (MPO) activity was measured in perihematoma.Results TNF-? immune reaction cells, ICAM-1 positive micro-vessels and MPO activity in perihematoma all increased strongly 3 d after ICH ( P
