Clinical Study of Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) on Drug Eruption Patients Over the last 10 years (1995-2004).
- Author:
Kyung Sool KWON
1
;
Byung Soo KIM
;
Bong Suk JANG
;
Moon Bum KIM
;
Chang Keun OH
;
Yoo Wook KWON
;
Ho Sun JANG
Author Information
1. Department of Dermatology, College of Medicine, Pusan National University, Busan, Korea. hsjang@pusan.ac.kr
- Publication Type:Original Article
- Keywords:
Pressure alopecia;
Local ischemia;
Recover;
Prevent
- MeSH:
Age of Onset;
Allopurinol;
Busan;
Captopril;
Carbamazepine;
Diagnosis;
Drug Eruptions*;
Eosinophilia*;
Exanthema*;
Humans;
Incidence;
Phenytoin;
Retrospective Studies
- From:Korean Journal of Dermatology
2005;43(9):1164-1169
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Drug rash with eosinophilia and systemic symptoms (DRESS), previously named drug `hypersensitivity syndrome', is a subset of severe drug eruption with quite distinct clinical presentations. Perhaps because of its relatively late onset and variable presentations, the diagnosis of DRESS may be delayed. OBJECTIVE: This study was designed to determine the incidence and investigate the causative drugs and clinical characteristics of DRESS. METHOD: We retrospectively reviewed the clinical features and laboratory findings of DRESS in 795 drug eruption patients who had visited Pusan National University Hospital over the last 10 years (1995-2004). RESULTS: 1. Of 795 drug eruption patients, 14 (1.76%) received a diagnosis of DRESS. 2. The average age of onset was 44.5 years and there was no significant difference according to sex. 3. The most common causative agent of DRESS was carbamazepine (50%), followed by allopurinol, captopril, phenytoin and antituberculous medications. 4. DRESS developed 2-10 weeks after administration of the causative agent, and the average latent period was 4.6 weeks.
