Antimicrobial resistance analysis among nosocomial gram-negative bacilli from 10 teaching hospitals in China
- VernacularTitle:2003—2004年中国十家教学医院革兰阴性杆菌的耐药分析
- Author:
Hui WANG
;
Minjun CHEN
;
Yuxing NI
;
Dongmei CHEN
;
Ziyong SUN
;
Yan CHEN
;
Wangsheng ZHAO
;
Xiong ZOU
;
Yunsong YU
;
Zhidong HU
;
Xinhong HUANG
;
Yingchun XU
;
Xiuli XIE
;
Yunzhuo CHU
;
Qian WANG
;
Yaning MEI
;
Bin TIAN
;
Pei ZHANG
;
Qinglian KONG
;
Xiujuan YU
;
Yuhong PAN
- Publication Type:Journal Article
- Keywords:
Gram-negative bacteria;
Drug monitoring;
Antimicrobials susceptibility tests;
Hospital,teaching
- From:
Chinese Journal of Laboratory Medicine
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
80% activity rate against E.coli included piperacillin/tazobactam(93.4%)、ceftazidime(86%),and amikacin(83.3%);The susceptible rate to piperacillin/tazobactam in K.pneumoniae was 84.6%. The susceptible rate to ceftazidime decreased from 82.3% to 69.9%, which was lower than to cefepime (77.2%). Over 50% of Enterobacter cloacae were resistant to ceftazidime, cefotaxime and ceftriaxone. Susceptible rates to piperacillin/tazobactam in E. cloacae,E. aerogenes,Citrobacter freundii and Serratia marcescens (67.7%-96.4%) were higher than those to cefepime (68.8%-77.5%), cefoperazone/sulbactam (59.7%-87.5%). Susceptibility to amikacin among these 4 species (70%-83.7%) was higher than to ciprofloxacin (48.1%-79.5%). All of Morganella morganii and Proteus vulgaris isolates were susceptible to meropenem and imipenem; Over 90% of the isolates were susceptible to cefepime, cefoperazone/sulbactam and piperacillin/tazobactam.The most active agent against Pseudomonas aeruginosa was meropenem (84%), followed by amikacin, piperacillin/tazobactam, ceftazidime and imipenem (72.5%-76.6%). Mutiple-drug-resistant Acinetobacter baumannii increased from 33% in 2003 to 48% in 2004. Resistance to carbapenems increased to 18% in this species in 2004. The most active agents against Burkholderia cepacia were meropenme (64.9%), cefoperazon/sulbactam (63.2%), ceftazidime (59.6%), piperacillin/tazobactam (56.1%) and cefepime (52.6%).Conclusions Carbapenems remained very high activity against Enterobacteriaceae. Increasing resistance to 10 antimicrobials agents tested among A. baumanni brought great concern. Meropenem was 4-to 16-fold more active against common gram-negative bacilli than imipenem.
