Quantitation of platelet GPIIb/IIIa occupancy and its application in analysis of patients with leukemia
- VernacularTitle:流式细胞术在血小板膜糖蛋白Ⅱb/IIIa位点定量检测中的应用及临床意义
- Author:
Liming PENG
;
Pei CAI
- Publication Type:Journal Article
- Keywords:
Flow cytometry;
Platelet glycoprotein GPⅡb/Ⅲa complex;
Leukemia
- From:
Chinese Journal of Laboratory Medicine
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To quantitate platelet GPIIb/IIIa occupancy and to evaluate the performance of the method, and investigate GPIIb/IIIa occupancy for the patients with leukemia.Methods GPIIb/IIIa occupancy was quantified by flow cytometry (FCM) and the method was evaluated according to guidelines published by NCCLS and ICSH; meanwhile,GPIIb/IIIa occupancy for 13 healthy donors and 16 patients with acute leukemia was investigated.Results The results demonstrated coefficients of variation (CV) for within-batch, between-batch and overall imprecision were
