The association between polymorphisims of aldose reductase gene and endothelial nitric oxide synthase and diabetic nephropathy
- VernacularTitle:两个基因多态性并存与糖尿病肾病的相关性研究
- Author:
Zhengliu XIAO
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
Diabetic nephropathy;
Endothelial nitric oxide synthase gene;
Aldose reductase gene;
Gene polymorphisim
- From:
Journal of Medical Postgraduates
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association between polymorphisims of both the 894G→T at exon 7 of endothelial nitric oxide synthase(eNOS) gene and the C-106T at promotor region of aldose reductase(AR) gene and type 2 diabetic nephropathy(DN) of Chinese. Methods: A case-control study for 202 Chinese subjects was performed.The genotypes and alleles of polymorphisims of 894G→T at exon 7 of eNOS gene and C-106T at promotor region of AR gene were determined by polymerase chain reaction restriction fragment lenth polymorphism method(PCR-RFLP). Results:The frequency of the T allele and TG genotype at exon 7 of eNOS gene and the T allele and CT genotype at promotor region of AR gene were significantly higher in DN+ group than that in DN-group and control group(P0.05).The type 2 diabetes with coexistence of the T allele/TG genotype of eNOS gene and T allele/CT genotype of AR gene had higher incidence of DN(P
