Osler-Weber-Rendu disease presenting with hepatocellular carcinoma: radiologic and genetic findings.
10.3350/kjhep.2011.17.4.313
- Author:
Joo Ho LEE
1
;
Yung Sang LEE
;
Pyo Nyun KIM
;
Beom Hee LEE
;
Gu Whan KIM
;
Han Wook YOO
;
Nae Yun HEO
;
Young Suk LIM
;
Han Chu LEE
;
Young Hwa CHUNG
;
Dong Jin SUH
Author Information
1. Department of Internal Medicine, Vievis Namuh Hospital, Seoul, Korea.
- Publication Type:Case Reports
- Keywords:
Osler-Weber-Rendu disease;
Hereditary hemorrhagic telangiectasia;
Hepatic arteriovenous malformation;
Hepatocellular carcinoma
- MeSH:
Activin Receptors, Type II/genetics;
Aged;
Angiography;
Carcinoma, Hepatocellular/*complications/*therapy;
Chemoembolization, Therapeutic;
Exons;
Gene Deletion;
Humans;
Liver Neoplasms/*complications/*therapy;
Male;
Mutation;
*Telangiectasia, Hereditary Hemorrhagic/complications/genetics/pathology/radiography;
Tomography, X-Ray Computed
- From:The Korean Journal of Hepatology
2011;17(4):313-318
- CountryRepublic of Korea
- Language:English
-
Abstract:
This is a case report of a 68-year-old man with hepatocellular carcinoma (HCC) accompanied by hereditary hemorrhagic telangiectasia (HHT), also known as Osler-Weber-Rendu disease, and hepatic vascular malformation. HHT is an autosomal dominant disorder of the fibrovascular tissue that is characterized by recurrent epistaxis, mucocutaneous telangiectasias, and visceral arteriovenous malformations. HHT is caused by mutation of the genes involved in the signaling pathway of transforming growth factor-beta, which plays an important role in the formation of vascular endothelia1. Hepatic involvement has been reported as occurring in 30-73% of patients with HHT. However, symptomatic liver involvement is quite rare, and the representative clinical presentations of HHT in hepatic involvement are high-output heart failure, portal hypertension, nodular regenerative hyperplasia, and symptoms of biliary ischemia. Some cases of HCC in association with HHT have been reported, but are very rare. We present herein the characteristic radiologic and genetic findings of HHT that was diagnosed during the evaluation and treatment of HCC.
